CORE THEMES
Inflammatory Bowel Disease
By deciphering how persistent immune dysregulation and mucosal damage spark genomic instability, we aim to uncover actionable biomarkers for early cancer detection, disease monitoring, and precision targeted therapies.
Ovarian and Breast Cancer
Focusing on breast and ovarian cancers, we investigate oncogenic transcriptional factors, epigenetic alterations, and tumor microenvironment remodeling to identify novel prognostic biomarkers and therapeutic targets.
Leukemia (Blood Cancer)
Our laboratory investigates the cellular and molecular mechanisms driving Acute Myeloid Leukemia (AML) and Acute Lymphoblastic Leukemia (ALL). Through advanced transcriptomic profiling, we focus on identifying novel diagnostic markers, targeting leukemic stem cells, and overcoming drug resistance.
Core Methodologies
Bulk RNA-Seq analysis to map transcriptomic dysregulation, mucosal barrier degradation, and inflammatory gene signatures.
Reconstructing oncogenic network topologies, transcription factor binding motif analysis, and master regulator identification.
Isolation and primary culture of Peripheral Blood Mononuclear Cells (PBMCs), intestinal epithelial cells, and lamina propria lymphocytes from clinical bio-samples.
2D/3D cancer cell line cultures, mammosphere/spheroid formation assays, invasion/migration assays, and drug-sensitivity screening.